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Figure 5 | Nonlinear Biomedical Physics

Figure 5

From: Characterizing Deep Brain Stimulation effects in computationally efficient neural network models

Figure 5

Effect of a simulation of the standard high-frequency deep brain stimulation, via four central electrodes, in terms synchronized activity of the coupled population of 100 neurons. (A) Bursting pattern during the excitatory stimulation; the membrane potentials v j (t) of 100 neurons are plotted, showing the characteristic synchronized and desynchronized bursting activity; (B) Synchronization measure R given by Eq. 13. In plots (A-B), the stimulation signal W(t), Figure 2, was formed by a 130 Hz pulse train composed out of biphasic pulses (0.2 ms positive followed by 3 ms negative stimulation). The stimulation was supplied via four electrodes situated in the central network. Parameters: X 1 = 1 for t [4.5,9]s, excitatory stimulation; X 1 = 0 elsewhere. DBS: Standard high-frequency deep brain stimulation.

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